Role of Hypouricemic Agents in Tumor Lysis Syndrome: A Meta-Analysis

Alshehri, Waleed and Aljohani, Abdulrahman and Alhasani, Reem and Alshammari, Anood and Alhamoud, Jwael A. and Alruwaili, Atheer and Altemani, Omniah and Bahabri, Ali and Alahmadi, Hassan and Alderaan, Shaykhah and Almutairi, Afnan and Alsehli, Marwan and Almohammadi, Mohammed and Almaleki, Faisal and Alotaibi, Hamoud (2021) Role of Hypouricemic Agents in Tumor Lysis Syndrome: A Meta-Analysis. Journal of Pharmaceutical Research International, 33 (33A). pp. 183-196. ISSN 2456-9119

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Official URL: https://doi.org/10.9734/jpri/2021/v33i33A31785

Abstract

Objective and background: Tumor lysis syndrome (TLS) is a life-threatening emergency and demands emergency care of effective outcome with minimal or no side effects. The Hypouricemic agents, including Rasburicase, Allopurinol and Febuxostate used for the management of TLS. This study was designed to evaluate the Role of Hypouricemic agents by analyzing TLS development rate, control of uric acid, and Creatinine levels.

Methods: An extensive electronic data search was conducted by using all leading scientific databases. Twenty-six studies were selected to conduct this study, as per the inclusion criteria.

Results: The Odd ratio of TLS development rate was 4.06, 1.24, and 1.49 by Rusbricase, Allopurinol & Febuxostate administration respectively. 95% confidence interval was reported by selected studies against TLS development rate, Uric acid, and Creatinine levels by administrating Rusbricase, Allopurinol & Febuxostate.

Conclusion: All Hypouricemic agents, including Rasburicase, Allopurinol and Febuxostate, are effective to manage Tumor lysis Syndrome. However, a suitable and most effective intervention dose needs to identify with better efficacy and minimal side effects both in Adults and Children.

Item Type:	Article
Subjects:	Oalibrary Press > Medical Science
Depositing User:	Managing Editor
Date Deposited:	06 Mar 2023 06:13
Last Modified:	23 Mar 2024 04:18
URI:	http://asian.go4publish.com/id/eprint/1017

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