Riva, Federica and Draghi, Susanna and Inglesi, Alessia and Filipe, Joel and Cremonesi, Paola and Lavazza, Antonio and Cavadini, Patrizia and Vigo, Daniele and Agradi, Stella and Menchetti, Laura and Di Giancamillo, Alessia and Aidos, Lucia and Modina, Silvia Clotilde and Fehri, Nour Elhouda and Pastorelli, Grazia and Serra, Valentina and Balzaretti, Claudia Maria and Castrica, Marta and Severgnini, Marco and Brecchia, Gabriele and Curone, Giulio (2024) Bovine Colostrum Supplementation in Rabbit Diet Modulates Gene Expression of Cytokines, Gut–Vascular Barrier, and Red-Ox-Related Molecules in the Gut Wall. Animals, 14 (5). p. 800. ISSN 2076-2615
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Abstract
Rabbits, pivotal in the EU as livestock, pets, and experimental animals, face bacterial infection challenges, prompting a quest for alternatives to curb antibiotic resistance. Bovine colostrum (BC), rich in immunoregulatory compounds, antimicrobial peptides, and growth factors, is explored for disease treatment and prevention. This study assesses BC diet supplementation effects on rabbit intestines, examining gene expression. Thirty female New Zealand White rabbits at weaning (35 days) were divided into three experimental groups: control (commercial feed), 2.5% BC, and 5% BC. The diets were administered until slaughtering (81 days). BC-upregulated genes in the jejunum included IL-8, TGF-β, and CTNN-β1 at 5% BC, while PLVAP at 2.5% BC. Antioxidant-related genes (SOD1, GSR) were downregulated in the cecum and colon with 2.5% BC. BC 5% promoted IL-8 in the jejunum, fostering inflammation and immune cell migration. It also induced genes regulating inflammatory responses (TGF-β) and gastrointestinal permeability (CTNN-β1). BC 5% enhanced antioxidant activity in the cecum and colon, but no significant impact on anti-myxo antibody production was observed. These results suggest that BC has significant effects on the rabbit gastrointestinal tract’s inflammatory and antioxidant response, but further research is required to fully understand its histological and physiological impact.
Item Type: | Article |
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Subjects: | Oalibrary Press > Multidisciplinary |
Depositing User: | Managing Editor |
Date Deposited: | 05 Mar 2024 07:47 |
Last Modified: | 05 Mar 2024 07:47 |
URI: | http://asian.go4publish.com/id/eprint/3695 |