Dental Treatment of a Child with Pallister-Killian Syndrome: Critical Research

The Pallister-Killian syndrome (PKS) is an extremely rare genetic disorder with an incidence
estimated around 1/25000 and a multiple congenital anomaly deficit syndrome caused by mosaic
tissue limited tetrasomy for chromosome 12p. The presented report is the first confirmed case with
PKS in Turkey. This report focuses on the orofacial clinical manifestations of an 6-year-old boy with
PKS who was referred to the Department of Paediatric Dentistry clinic, Gazi University. It has been
learned that the PKS was diagnosed 1 year after birth. Due to intellectual disability, it was decided to
make the dental treatments under moderate sedation. Although significant tongue thrust and anterior
open bite were determined, any oral appliances could not be applied because of the 2 epilepsy
seizures in the last 2 years. The aim was to treat decayed teeth and set good oral hygiene in the
patient’s mouth. Still, there is a probability for epilepsy seizures. If epileptic seizures stop permanently,
we can apply an oral appliance to block tongue thrust. The patient is now under control. In cases of
systemic and oral findings such as PKS, conducting medical and dental approaches together will
increase the life quality of patients.