Investigation on the Optimization and Evaluation of Temperature Triggered in Situ Hydrogels for an Effective Treatment of Ophthalmic Preparations–A Perlustration

This work reviews on the optimization and evaluation of pluronic polymers based thermo-responsive
in-situ hydrogels which is used specifically for ophthalmic purposes. The method of preparation using
cold method and different physicochemical properties that affect hydrogel preparations include pH,
flow ability, transition of sol–gel, temperature, gelling capacity and rheological properties were briefly
reviewed. Based on in-vitro release studies and gelling capacity, how the best formulation could be
selected and analyzed has been widely discussed in this work. Literature reports on the study of
different autoclaving (both before and after) and irritation studies in rabbits were reviewed. In addition,
the aqueous humour analysis done using albino rabbits was also reported. Through this review, it was
inferred that the increase in pluronic polymer concentration increase the physiochemical property of
sol–gel transition temperature. Further, these types of hydrogels are widely established as secured
especially for usage ophthalmic products and it might significantly improve drug bioavailability in
humour analysis. It is concluded that the optimized in-situ hydrogels could be a promising substitute to
conventional eye drops.