TWO SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF GRISEOFULVIN IN TABLETS

Two simple and rapid spectrophotometric methods have been described for the assay of griseofulvin (GRF) either in pure form or in pharmaceutical formulations. The first method (A) is based on charge transfer complex reaction using 7,7,8,8-tetracyanoquinodimethane (TCNQ). The complex showed absorbance maximum at 842 nm. Beer's law is obeyed over the concentration range of 5–200 μg mL−1. The second method (B) is based on the formation of coloured ethylenechloride extractable ion-association complex of GRF with Mo(V)-thiocyanate with absorption maximum at 470 nm. Beer’s law is obeyed in the concentration range of 2-150 μg mL-1. The proposed methods were applied successfully to the determination of the examined drug either in a pure or pharmaceutical dosage forms. No interference was observed from common excipients present in pharmaceutical formulations.