Diagnostic accuracy of m2 pyruvate kinase quick stool test and fecal occult blood test for detection of colorectal cancer

Background: Colorectal cancer (CRC) is the fourth most common cancer leading to death in the world. The main goal of screening methods are to detect cancer at its early stages. The aim of this study was to determine the diagnostic accuracy of M2pk and fecal occult blood test.

Methods: The patients with recent GI complaint underwent colonoscopy divided in two groups: A: positive finding in colonoscopy B: normal colonoscopy. All the patients provided fecal samples prior to bowel preparation.

Results: 102 patients with GI complaint (60.78% male and 39.22% female) with the mean age of 54.14 years old were included in our study. In the group of patient with positive m2pk level 83% of them have positive FOBT (p<0.05). Sensitivity, specificity, PPV and NPV for the test of m2pk are with respect 64% / 84% / 80% / 71%, respectively and for FOBT are 84% / 82% / 83% and 84, respectively %.

Conclusion: The sensitivity, PPV and NPV fecal occult blood test in predicting lower GI complications such as polyp and intraluminal mass are higher than m2pk levels. Only the specificity of m2pk levels is higher than FOBT. So the result of m2pk in prediction normal patients is higher than FOBT. Also the relation between FOBT and m2pk levels is statistically significant in prediction lower GI cancers.