Diclofenac-induced Gastric Ulceration in Rats: Protective Roles of Pantoprazole and Misoprostol

El-Deen, E and El-Mahdy, N and Rashidy, M and Ghorab, M and Gad, Shadeed and Yassin, H (2016) Diclofenac-induced Gastric Ulceration in Rats: Protective Roles of Pantoprazole and Misoprostol. British Journal of Pharmaceutical Research, 11 (3). pp. 1-12. ISSN 22312919

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Abstract

Gastrointestinal damage caused by diclofenac remains a significant clinical problem. Pantoprazole provides potent and long-lasting inhibition of gastric acid secretion and has proven efficacy in healing diclofenac-associated ulcers, including those with continued exposure to diclofenac. The objective of this study was to prepare and evaluate microbeads of diclofenac sodium coated with sodium alginate and Hydroxypropylmethylcellulose (HPMC) in order to obtain controlled release drug delivery system. The ulcerogenic activity and histopathological effects of the prepared formulation were compared with a marked formula containing the drug with misoprostol which orally administered to male Wistar rats. Ionotropic gelation technique was the technique of choice to encapsulate the drug. IR spectral analysis indicated no interaction between the drug and polymers used. Microbeads which showed a significant reduction in the release of diclofenac at acidic pH of the stomach as well as maximal release at alkaline pH of the intestine were selected to conduct further in vivo evaluation. The beads were administered to rats in combination with pantoprazole. The obtained ulcer index as well as the histopathological effects of the proposed formulations was compared to marketed formula containing the drug combined with misoprostol. The obtained In vivo results indicate that administration of pantoprazole and diclofenac microbeads has shown efficacy in reducing the risk of GIT ulcerations compared with administration of misoprostol and diclofenac or diclofenac separately.

Item Type: Article
Subjects: Oalibrary Press > Medical Science
Depositing User: Managing Editor
Date Deposited: 09 Jun 2023 04:21
Last Modified: 02 Feb 2024 04:14
URI: http://asian.go4publish.com/id/eprint/2205

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