The Effects of Ozone Therapy on the Expression of IL-8, IL-10, CXCL9 and CXCL11 in Joint Fluid in Patients with Knee Osteoarthritis

Knee joint is one of the common sites of osteoarthritis (OA) with manifestation of localized joint swelling, pain and deformity, often seriously affecting daily work and life. It was found that the activation of Janus kinase / signal transducer and activator of transcription 3 (JAK / STAT3) signal pathway can lead to osteoarthritis. JAK-STAT signal transduction pathway is closely related to painful diabetic peripheral neuropathy and participates in neuropathic pain. Ozone therapy is often used for alleviating pain in neck, shoulder, waist and leg due to its oxidative, anti-inflammatory and analgesic effects. In recent years, ozone therapy is promising in treating knee osteoarthritis, which can significantly reduce the pain and swelling of the joints. The mechanism of ozone for knee osteoarthritis remains unclear and might associated with inhibition of inflammatory factors and matrix metalloproteinase activity, and intervention of free radical metabolism. In this study, the efficacy of ozone in the treatment of OA and its effect on inflammatory factors were evaluated by knee joint cavity ozone injection and detecting the expression of inflammatory factors IL-8, IL-10, CXCL9 and CXCL11 in joint fluid.