Synthesis of α-Naphthol and 2,4,7-Trimethyl-Quinolin-5-ol by Using Manganese (III) Acetate and Analysis of Its Antimicrobial Properties

This study involves the aromatization reactions of some ketone derivatives through Manganese (III) acetate. The ketone derivatives used in the study are α-tetralone (1a), 2,4,7-trimethyl-7,8-dihydro quinolinone (1b). At the end of the aromatization reactions of these ketone derivatives the synthesized structures of α-naphthol (2a), 2,4,7-trimethylquinoline-5-ol (2b) were identified by spectroscopic methods such as IR, 1H-NMR, 13C-NMR, FAB-MS respectively. Micro-organism types such as Escherichia coli, ATCC 25922, Klepsiella pneumoniae, Staphylococcus aureus NRRL B767, Salmonella typhimurium NRRLB 4420, Bacillus subtilis NRS 744, Bacillus cereus ATCC 11778, Micrococcus luteus ATCC-9341, Listeria monoaytopenus ATCC-7644 bacteria and yeast fungus Candida albicans were used to study the anti-microbial properties of the synthesized 2b compound. The obtained results have determined that compound number 2b has a good antibacterial impact on Bacillus subtilis (NRS-744).